Welcome to the PANS Pandemic Educational (PPE) Series 20/21
PROUDLY SPONSORED BY STOELTING: Your source for Stereotaxic, Neuroscience and Behavior research instruments (https://www.stoeltingco.com/)
PANS will host a virtual seminar once every two months on the last Friday of the month at noon EST.
Save the date for the 5th PANS PPE – May 28, 2021.
Invited speaker: Martin Myers, MD PhD
Professor of Internal Medicine and Molecular
& Integrative Physiology, University of Michigan
Presenting ‘CNS control of metabolism’
Details to be posted soon.
PAST PPE SEMINARS
Mini-symposium for young(ish) investigators
12-12:30 pm – Alejandro Lomniczi, OHSU, USA
Title: Unravelling the Role of Epigenetics in the Metabolic Control of Puberty
12:30-1:00 pm – Renata Frazão, Universidade de São Paulo, Brazil
Title: Hormonal inputs to hypothalamic components of the HPG axis: Puzzle pieces.
1:00-1:30 pm – Kellie Breen Church, UC San Diego, USA
Title: Neural circuits controlling reproduction: implications for stress-activated pathways
1:30-2:00 pm – Claudio Perez-Leighton, Pontificia Universidad Católica de Chile, Santiago, Chile
Title: Neuropeptides and control of food intake: GLP1, orexin and dynorphins.
Our studies focus on the molecular, cellular and physiological actions of steroid hormones in the brain. Ovarian estrogens exert critically important actions in specific neuronal populations to regulate ovulatory cyclicity, reproductive behaviors, energy homeostasis and body weight. Estrogen receptor alpha (ERα) appears to mediate most of these effects, as disruption of ERα signaling leads to infertility and metabolic syndrome. ERα signaling mechanisms may include “classical genotropic” effects mediated by direct binding of receptor dimers to DNA, “non-classical genotropic” effects involving tethering of ERs to other transcription factors and “non-classical non-genotropic” actions mediated by cytoplasmic ERs coupled to membrane-initiated signal transduction pathways. Our studies are making use of conditional gene targeting to ascertain the cellular mechanisms by which ERα mediates E2 effects on these physiological and behavioral processes. We have utilized a novel mutant ERα knock-in mouse model, which confers non-classical genotropic and non-genotropic signaling in the absence of classical signaling, to determine that non-classical ERα signaling can convey E2 effects integral to homeostatic feedback control of reproductive hormone secretions, as well as E2 actions governing metabolic function and body weight regulation. We are currently developing viral vector-mediated gene knockdown approaches to probe these important signaling mechanisms in non-human primates.
Institute of Biology and Experimental Medicine (IBYME)
National Research Council of Argentina
Our laboratory has worked for almost 20 years unraveling the regulation of the pituitary, both in normal physiology and in pathological states. We study the biochemical, physiological and molecular mechanisms that regulate pituitary function, and the effect of hormones at the central nervous system, in reproduction and metabolic control. One of our aims is to propose alternative therapies in dopamine agonist resistant prolactinomas. We work with two transgenic mouse models which lack the dopamine receptor D2, and with human samples of resistant prolactinomas. We also study the role of sexual differentiation of the hypothalamus in pituitary control, and its impact on GH regulation of hepatic sexual dimorphism. We have recently undertaken the study of the participation of the pituitary in pancreatic function, in particular, trying to understand the development of type 2 diabetes in antipsychotic treatments. Our laboratory also studies the role of the pituitary in milk production and parasite infection in dairy heifers in Argentine farms.
Title: “Prolactin in health and disease: metabolic actions at brain centers modifying pancreatic, adipose tissue and liver functions”.
Professor College of Pharmacy,
Department of Psychology
Mildred Hajek Vacek and John Roman Vacek Chair in Pharmacology, in Honor of Professor C. C. Alber
Work in the Gore Laboratory focuses on the neuroendocrine control of reproduction, and connections among hormones, brain sexual differentiation, and behavior. Current research seeks to understand how prenatal exposure to environmental endocrine disruptors (EDCs) causes molecular epigenetic modifications and cellular changes to the developing hypothalamus and the manifestations of these effects later in life, and transgenerationally. We also have a longstanding interest in brain aging and menopause, and how hormones such estrogens affect molecular and cellular properties of the brain.